Peripheral blood stem cells

What are peripheral blood stem cells

The peripheral blood stem cell (PBSC) separation technique is used to that the process is similar to blood donation. Before collection, it is necessary to inject granulocyte colony stimulating factor (GCSF), for several consecutive days. After injection of G-CSF, hematopoietic stem cells (HSC) in the bone marrow can be driven into the peripheral blood. At this time, a large amount of HSC can be obtained through the technology of blood separation. The HSC collection also have no anesthesia-related risk considerations, and the recovery time is short, and quickly return to normal life.

Leopard Cells has accumulated more than ten years of adult stem cell research and development experience, and advocates that the storage of stem cells should be prioritized for “self-preservation and self-use”, just like the concept of a healthy passbook. Therefore, everyone is suitable for saving, and the timing of extraction and use can be properly planned. PBSC can not only be used to treat blood, immunity, cancer and other related diseases, but also can be used in functional medicine and anti-aging medicine. Many of their advantages have gradually replaced bone marrow transplantation.

The comparison of peripheral blood stem cells and marrow

Collection source Adult peripheral blood Marrow
Applicable ethnic group The general public who values health,
Those with a family history of cancer.
Donation, but it has almost been replaced by peripheral blood stem cells
Collection method Use a blood separator to collect surrounding stem cells. General anesthesia and bone marrow extraction
Acquisition time Stimulates stem cells in the bone marrow to move and release into the blood around adults. The stimulation is about 3 to 5 days, and the collection takes 3 to 4 hours. Inpatient surgery extraction requires at least 4 to 6 months of preparatory time.
The source of bone marrow is not easy, and donors can easily regret it.
Collection container Blood bag Bone marrow puncture needle and syringe
Collection side effects No risk of general anesthesia The danger of surgical anesthesia and body pain after the anesthesia subsides
Rejection Self-preservation and use, no rejection The danger of surgical anesthesia and body pain after the anesthesia subsides
Self-use opportunities High Approaching zero
Number of transplantation cases Has gradually replaced bone marrow transplantation Longer development, more transplant cases

Peripheral blood is one of the sources of HSC transplantation. In addition to self-renewal and differentiation into blood and immune cells, hematopoietic stem cells can now be used to treat blood and immune system diseases, such as leukemia, lymphoma, anemia, and mucopolysaccharidosis. It can also be used as a cancer treatment option. The hematopoietic and immune systems destroyed by cancer patients during chemical or radiotherapy can also be restored by PBSC. Store PBSC when you are young and have one more medical option when you are in urgent need, will be important risk management. PBSC transplantation has gradually replaced bone marrow transplantation because of its many advantages:

  • It is easy to obtain and suitable for the general public.
  • High safety, no risk related to anesthesia
  • It can be stored and used by itself without rejection.
  • Compared with bone marrow extraction, peripheral blood storage can remove the danger and inconvenience caused by anesthesia, and there will be no harm or pain during the collection process.
  • Instant, available immediately after thawing cell.
  • After the collection, the recovery time is shorter, and the return to normal life is quicker.

International Stem Cell Storage

  • Lihpao Life Science integrates ISO9001 and GTP double standards to establish a laboratory quality management and quality assurance system, has a repository that meets GTP specifications, and has multiple certifications and extensions. The clean area for cell processing is set up in accordance with the ISO international standards. The main process area environment is recommended by the Department of Health and set up at ISO level 7; the biological sterile safety operating table is set up at ISO level 5 to ensure that there are no cells in the process. The possibility of cross-contamination or microbial contamination maintains the quality of cells. In the clean area, there is a central control system that monitors all environmental changes in the area, and comprehensive and regular monitoring of temperature, humidity, pressure difference and cleanliness to ensure air quality, maintain process and cell safety.
  • Standardized operating procedures ensure consistent manufacturing processes and ensure cell quality and safety. In order to improve laboratory testing capabilities and credibility, in addition to using IVD-certified testing instruments with its exclusive quality control liquid, the laboratory’s quality control system has been established, and the ability to participate in relevant domestic and foreign testing projects, such as the College of American Pathologists (CAP) and the Taiwan Medical Laboratory Science Association, etc., make the laboratory’s testing capabilities equal to that of international laboratories.
  • Leopard Cells has established a depository for many years and has accumulated more than one hundred VIP customers for storage, and is actively engaged in the development of peripheral blood stem cell product applications.

Clean area

The high-standard clean area is installed to ensure that all cell processing processes are carried out in a clean area of class 10000 (ISO 7). Strictly control microorganisms and dust particles to ensure that cells do not produce cross-contamination or microbial contamination during operation.

  • Dust-free seamless design: Set up anti-static dust-free sandwich library version and conductive seamless floor.
  • Positive pressure control: Set the pressure gradient to 15Pa according to the GMP standard to protect the product from contamination.
  • Air barrier: The space is airtight to prevent air leakage; the ceiling is equipped with a high-efficiency filter to maintain cleanliness.
  • Strict movement planning: Strictly control the entry and exit of personnel, and there are plans for the flow of people, logistics, and machinery.

Test area

Use the automatic blood cell counter and flow cytometer used by the clinical testing unit for product quality inspection. All products must be inspected before and after treatment to confirm that there is no pollution before and after the process to ensure product quality.

Storage area

Cell products are stored in large gas-phase liquid nitrogen storage tanks, and are equipped with an automatic monitoring system, which can automatically fill liquid nitrogen and record the storage status, and the environmental equipment is equipped with an automatic alarm system. When an abnormal situation occurs, the storage tank will activate an alarm system to automatically notify the staff on duty to handle it, ensuring the safety and quality of product storage.

Product Description

Collection process of peripheral blood stem cells

Features

  • No anesthesia

  • Pain relieve

  • Enhancing safety

  • Reduce infection

  • Recovery of platelet function quickly

Store peripheral blood stem cells early!

The top ten causes of death among Taiwanese people, “cancer” has ranked first for 37 consecutive years, and its treatment methods are nothing more than surgery, chemotherapy, radiotherapy or targeted drugs. After treatment, most patients feel exhausted physically and mentally, and may cause various side effects, which have a great impact on the lives of patients. With the development of medical technology, hematopoietic stem cells help yourself for enhancing health.

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